AQUILI Luca    所属   立命館アジア太平洋大学  国際経営学部    職種   准教授
言語種別	英語
発行・発表の年月	2022
形態種別	学術論文
査読	査読あり
標題	Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies
執筆形態	分担
掲載誌名	FRONTIERS IN NEUROENDOCRINOLOGY
掲載区分	国外
巻・号・頁	65
国際共著	国際共著
著者・共著者	Roy Jaydeep, Wong Kan Yin, Aquili Luca, Uddin Md. Sahab, Heng Boon Chin, Tipoe George Lim, Wong Kah Hui, Fung Man Lung, Lim Lee Wei
概要	This review traces melatonin research in Alzheimer’s disease from preclinical mechanisms to emerging therapies. It summarizes evidence that melatonin may reduce oxidative stress, neuroinflammation, amyloid and tau pathology, while supporting sleep, circadian regulation, and cognition. Clinical studies have examined sleep, behavior, cognitive outcomes, electrophysiology, and biomarkers in mild cognitive impairment and Alzheimer’s disease, but remain heterogeneous and limited. The article also evaluates melatonin analogues, derivatives, and hybrid molecules designed to improve potency or target multiple pathways. Overall, the therapeutic rationale is strong, but definitive clinical trials are still needed.
DOI	10.1016/j.yfrne.2022.100986
ISSN	0091-3022