AQUILI Luca    所属   立命館アジア太平洋大学  国際経営学部    職種   准教授
言語種別	英語
発行・発表の年月	2021
形態種別	学術論文
査読	査読あり
標題	Functional Roles of Neuronal Nitric Oxide Synthase in Neurodegenerative Diseases and Mood Disorders
執筆形態	分担
掲載誌名	CURRENT ALZHEIMER RESEARCH
掲載区分	国外
巻・号・頁	18(10),pp.831-840
国際共著	国際共著
著者・共著者	Poon Chi H., Tsui Ka C., Chau Sze C., Chong Pit S., Lui Sylvia W. Y., Aquili Luca, Wong Kah H., Lim Lee W.
概要	This review summarizes the physiological and pathological roles of neuronal nitric oxide synthase, the principal neuronal source of nitric oxide. Under normal conditions, nNOS supports synaptic transmission, plasticity, learning, and memory. Dysregulated activity can instead contribute to oxidative and nitrosative stress in Alzheimer’s disease, Parkinson’s disease, and mood disorders. The article compares disease-specific changes in nNOS localization and signaling and considers therapeutic opportunities. Because nitric oxide can be protective or toxic depending on concentration, timing, and cellular context, successful interventions will require selective modulation rather than broad inhibition.
DOI	10.2174/1567205018666211022164025
ISSN	1567-2050