AQUILI Luca    所属   立命館アジア太平洋大学  国際経営学部    職種   准教授
言語種別	英語
発行・発表の年月	2025
形態種別	学術論文
査読	査読あり
標題	Data Mining Approach to Melatonin Treatment in Alzheimer’s Disease: New Gene Targets MMP2 and NR3C1
執筆形態	分担
掲載誌名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
掲載区分	国外
巻・号・頁	26(1)
国際共著	国際共著
著者・共著者	Zhang Jingyi, Tsui Ka Chun, Lee Hoi Ying, Aquili Luca, Wong Kah Hui, Kocabicak Ersoy, Temel Yasin, Lu Zhiliang, Fung Man-Lung, Kalueff Allan, Lim Lee Wei
概要	This study used data-mining and network-analysis methods to identify underexplored molecular targets through which melatonin may act in Alzheimer’s disease. Integrating genes associated with melatonin and Alzheimer-related pathways produced two prominent clusters centered on MMP2 and NR3C1. These genes connect steroid-hormone signaling, apoptosis, monoamine neurotransmission, amyloid clearance, and neuroinflammatory processes. The analysis expands the mechanistic focus beyond melatonin’s established antioxidant and anti-amyloid actions. MMP2 and NR3C1 are proposed as priority targets for experimental validation, biomarker development, and studies of how melatonin modifies Alzheimer’s pathophysiology.
DOI	10.3390/ijms26010338
ISSN	1661-6596