AQUILI Luca    所属   立命館アジア太平洋大学  国際経営学部    職種   准教授
言語種別	英語
発行・発表の年月	2020
形態種別	学術論文
査読	査読あり
標題	Therapeutic potential of neurogenesis and melatonin regulation in Alzheimer's disease
執筆形態	分担
掲載誌名	ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
掲載区分	国外
巻・号・頁	1478(1),pp.43-62
国際共著	国際共著
著者・共著者	Mihardja Mazel, Roy Jaydeep, Wong Kan Yin, Aquili Luca, Heng Boon Chin, Chan Ying-Shing, Fung Man Lung, Lim Lee Wei
概要	This review examines impaired adult neurogenesis in Alzheimer’s disease and evaluates melatonin as a regulator of neuronal renewal and survival. It integrates evidence linking circadian disruption, oxidative stress, inflammation, and reduced hippocampal neurogenesis with cognitive decline. Preclinical studies indicate that melatonin can support neural progenitor proliferation, differentiation, survival, and memory-related function through several converging pathways. The authors identify melatonin-regulated neurogenesis as a promising therapeutic direction, while emphasizing that dosing, timing, disease stage, and limited clinical evidence must be resolved before preclinical benefits can be translated into treatment.
DOI	10.1111/nyas.14436
ISSN	0077-8923