AQUILI Luca    所属   立命館アジア太平洋大学  国際経営学部    職種   准教授
言語種別	英語
発行・発表の年月	2020
形態種別	学術論文
査読	査読あり
標題	Serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation
執筆形態	分担
掲載誌名	BRAIN STRUCTURE & FUNCTION
掲載区分	国外
巻・号・頁	225(7),pp.1957-1966
国際共著	国際共著
著者・共著者	Tan Shawn Zheng Kai, Temel Yasin, Chan Ariel Yovela, Mok Andrea Tsz Ching, Perucho Jose Angelo Udal, Blokland Arjan, Aquili Luca, Lim Wei Ling, Lim Lee Wei
概要	This rat study examined how serotonergic treatments alter fear behavior and midbrain dopamine changes induced by periaqueductal gray stimulation. Acute escitalopram, but not buspirone, reduced anticipatory freezing, while chronic administration of either drug produced an anxiolytic effect. Stimulation increased the number of tyrosine-hydroxylase-positive neurons in the ventral tegmental area, and chronic serotonergic treatment normalized this increase. The findings connect therapeutic effects on defensive behavior with adaptations in midbrain dopamine systems, suggesting that serotonin-based treatments may regulate fear partly by restoring stimulation-induced dopaminergic imbalance.
DOI	10.1007/s00429-020-02102-w
ISSN	1863-2653