AQUILI Luca    所属   立命館アジア太平洋大学  国際経営学部    職種   准教授
言語種別	英語
発行・発表の年月	2019
形態種別	学術論文
査読	査読あり
標題	Dissociable Effects of Tryptophan Supplementation on Negative Feedback Sensitivity and Reversal Learning
執筆形態	コレスポンディング
掲載誌名	FRONTIERS IN BEHAVIORAL NEUROSCIENCE
掲載区分	国外
巻・号・頁	13
国際共著	国際共著
著者・共著者	Thirkettle Martin, Barker Laura-Marie, Gallagher Thomas, Nayeb Nazgol, Aquili Luca
概要	This placebo-controlled experiment separated two processes often treated as equivalent: sensitivity to negative feedback and the ability to reverse a learned choice. Forty-four healthy participants received tryptophan or placebo before completing probabilistic learning tasks. Tryptophan increased behavioral sensitivity to negative feedback but did not improve probabilistic reversal learning. The dissociation indicates that serotonergic precursor availability can alter how strongly people respond to unfavorable outcomes without necessarily improving flexible updating of established stimulus–reward associations. The study therefore refines accounts linking serotonin broadly to punishment processing and cognitive flexibility.
DOI	10.3389/fnbeh.2019.00127
ISSN	1662-5153