AQUILI Luca    所属   立命館アジア太平洋大学  国際経営学部    職種   准教授
言語種別	英語
発行・発表の年月	2018
形態種別	学術論文
査読	査読あり
標題	A dopaminergic switch for fear to safety transitions
執筆形態	分担
掲載誌名	NATURE COMMUNICATIONS
掲載区分	国外
巻・号・頁	9
国際共著	国際共著
著者・共著者	Luo Ray, Uematsu Akira, Weitemier Adam, Aquili Luca, Koivumaa Jenny, McHugh Thomas J., Johansen Joshua P.
概要	This study used projection-specific manipulations to explain how dopamine supports the transition from fear to safety during extinction. Omission of an expected aversive event activated ventral tegmental dopamine neurons, and this signal was required for extinction learning and associated molecular changes. Projections to the medial nucleus accumbens shell promoted extinction, whereas projections to medial prefrontal cortex opposed it. The findings reveal that a common midbrain dopamine source can exert opposite effects through distinct pathways, creating a circuit-level switch that determines whether defensive responding is maintained or updated toward safety.
DOI	10.1038/s41467-018-04784-7
ISSN	2041-1723