AQUILI Luca    所属   立命館アジア太平洋大学  国際経営学部    職種   准教授
言語種別	英語
発行・発表の年月	2014
形態種別	学術論文
査読	査読あり
標題	Behavioral flexibility is increased by optogenetic inhibition of neurons in the nucleus accumbens shell during specific time segments
執筆形態	筆頭著者
掲載誌名	LEARNING & MEMORY
掲載区分	国外
巻・号・頁	21(4),pp.223-231
国際共著	国際共著
著者・共著者	Aquili Luca, Liu Andrew W., Shindou Mayumi, Shindou Tomomi, Wickens Jeffery R.
概要	This optogenetic study identified when nucleus accumbens shell activity contributes to behavioral flexibility during reversal learning. Neurons were inhibited either while rats selected an action or while they processed feedback. Inhibition during choice had little effect, whereas inhibition during the outcome period reduced reversal errors and increased switching after losses. The results indicate that accumbens shell activity can constrain flexible updating specifically when negative outcomes are integrated, rather than during action selection itself. Precisely timed inhibition revealed a causal window in which this region regulates adaptation to changed contingencies.
DOI	10.1101/lm.034199.113
ISSN	1072-0502