オクヤマ　リョウ   OKUYAMA Ryo   奥山 亮    所属   立命館アジア太平洋大学  国際経営学部    職種   教授
言語種別	英語
発行・発表の年月	2023/07
形態種別	学術論文
査読	査読あり
標題	Advancements in Drug Repurposing: Examples in Psychiatric Medications.
執筆形態	単著
掲載誌名	International Journal of Molecular Sciences
掲載区分	国外
出版社・発行元	MDPI
巻・号・頁	24(13),pp.11000
総ページ数	10
担当区分	筆頭著者,責任著者
著者・共著者	Ryo Okuyama
概要	This study was aimed at uncovering recent trends in drug repurposing approaches and new technologies in psychiatric drug development. Psychiatric drugs that were approved by the FDA between 2002 and 2022 were listed, and the method of how the drug repurposing has been applied was analyzed. Drug repurposing has been increasingly applied to recently approved psychiatric drugs. All repurposed drugs approved before 2016 used either prodrugs or active metabolites, while all drugs approved in 2021 and beyond used fixed-dose combinations with sophisticated ideas. SmartCube®, which uses artificial intelligence to predict human drug efficacy from animal phenotypes, was developed and produced novel drugs that show clinical efficacy. Well-designed drug repurposing approaches and new technologies for predicting human drug efficacy based off of animal models would contribute to novel psychiatric drug development.
DOI	https://doi.org/10.3390/ijms241311000