AQUILI Luca    所属   立命館アジア太平洋大学  国際経営学部    職種   准教授
言語種別	英語
発行・発表の年月	2025
形態種別	学術論文
査読	査読あり
標題	DNA Methylation: A Potential Mediator of the Memory Regulatory Effects of taVNS
執筆形態	分担
掲載誌名	Cells
掲載区分	国外
巻・号・頁	14(17),pp.1327
国際共著	国際共著
著者・共著者	Pak On Patrick Yee, Ka Chun Tsui, Man Lung Fung, Boon Chin Heng, Ersoy Kocabicak, Ali Jahanshahi, Yasin Temel, Arjan Blokland, Luca Aquili, Allan Kalueff, Kah Hui Wong, Lee Wei Lim
概要	This review proposes DNA methylation as a mechanism through which transcutaneous auricular vagus nerve stimulation may regulate memory. It first summarizes the neurophysiological and biochemical pathways engaged by auricular stimulation, then examines how methylation regulators such as DNMT3a and readers such as MeCP2 influence learning and synaptic plasticity. Because neuronal activity can modify these epigenetic processes, stimulation may produce durable memory effects by altering gene regulation. The hypothesis is plausible but not yet directly established, so the article outlines experiments needed to test causal molecular links and optimize stimulation.
DOI	https://doi.org/10.3390/cells14171327