ローズ ジョン   ROSE John A.    所属   立命館アジア太平洋大学  アジア太平洋学部    職種   教授
言語種別	英語
発行・発表の年月	1997/10
形態種別	論文（その他）
査読	査読あり
標題	A DNA Based Artificial Immune System for Self-Nonself Discrimination
執筆形態	共著
掲載誌名	IEEE International Conference on Systems, Man, and Cybernetics (Proceedings)
巻・号・頁	pp.369-374
著者・共著者	R. Deaton, M. Garzon, J. A. Rose, D. R. Franceschetti, R. C. Murphy, and S. E. Stevens, Jr.
概要	Artificial immune systems attempt to distinguish self from nonself through string matching operations. A detector set of strings is selected by eliminating random strings that match the self strings. DNA based computers have been proposed to solve complex problems (e.g. Traveling Salesman) that defy solution on conventional computers. They are based on (hydrogen bonding based) matchings (called hybridizations) between Watson-Crick complementary pairs, A-T (Adenine-Thymine) or C-G (Cytosine-Guanine). Therefore, a single strand (an oligonucleotide) will bind with other oligonucleotides that match most closely its sequence under the operation of Watson- Crick complementation. In this paper, an algorithm for implementing an articial immune system for selfnonself discrimination based on DNA is described. This procedure takes advantage of the inherent pattern matching capability of DNA hybridization reactions and the notion of similarity naturally found in DNA hybridization. Note: (Orlando, FL, Oct 12-15, 1997)