AQUILI Luca    所属   立命館アジア太平洋大学  国際経営学部    職種   准教授
言語種別	英語
発行・発表の年月	2023
形態種別	学術論文
査読	査読あり
標題	Prelimbic Cortical Stimulation Induces Antidepressant-like Responses through Dopaminergic-Dependent and -Independent Mechanisms
執筆形態	分担
掲載誌名	CELLS
掲載区分	国外
巻・号・頁	12(11)
国際共著	国際共著
著者・共著者	Khairuddin Sharafuddin, Lim Wei Ling, Aquili Luca, Tsui Ka Chun, Tse Anna Chung-Kwan, Jayalath Shehani, Varma Ruhani, Sharp Trevor, Benazzouz Abdelhamid, Steinbusch Harry, Blokland Arjan, Temel Yasin, Lim Lee Wei
概要	This study investigated dopamine-dependent and dopamine-independent mechanisms of high-frequency prelimbic cortical stimulation in rats exposed to stress. Animals were classified as susceptible or resilient according to depressive-like behavior, then assessed after stimulation and dopaminergic manipulations. Prelimbic stimulation produced robust antidepressant-like responses across behavioral and biological measures, but blocking dopamine signaling did not eliminate every benefit. The findings indicate that dopamine contributes importantly to the therapeutic response while parallel pathways also support resilience and recovery. This mechanistic diversity may explain why cortical stimulation can remain effective despite heterogeneous neurochemical states.
DOI	10.3390/cells12111449
ISSN	2073-4409