AQUILI Luca    所属   立命館アジア太平洋大学  国際経営学部    職種   准教授
言語種別	英語
発行・発表の年月	2023
形態種別	学術論文
査読	査読あり
標題	Prelimbic Cortical Stimulation with L-methionine Enhances Cognition through Hippocampal DNA Methylation and Neuroplasticity Mechanisms
執筆形態	分担
掲載誌名	AGING AND DISEASE
掲載区分	国外
巻・号・頁	14(1),pp.112-135
国際共著	国際共著
著者・共著者	Poon Chi Him, Liu Yanzhi, Pak Sojeong, Zhao Robert Chunhua, Aquili Luca, Tipoe George Lim, Leung Gilberto Ka-Kit, Chan Ying-Shing, Yang Sungchil, Fung Man-Lung, Wu Ed Xuekui, Lim Lee Wei
概要	This animal study tested whether L-methionine enhances the memory effects of high-frequency prelimbic cortical stimulation during aging. Combined treatment improved hippocampal-dependent spatial memory and promoted DNMT3a-dependent DNA methylation, neuroplasticity-related gene expression, neurogenesis, and monoaminergic signaling while suppressing calcineurin. Blocking hippocampal DNA methyltransferases reproduced age-related deficits and abolished the stimulation benefit, establishing a causal role for methylation. The results identify hippocampal DNMT activity as a key mediator of neuromodulation-induced memory improvement and suggest that methyl-donor support may augment future stimulation-based interventions for cognitive decline.
DOI	10.14336/AD.2022.0706
ISSN	2152-5250