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OKUYAMA Ryo
Department Ritsumeikan Asia Pacific University College of International Management Position Professor |
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| Language | English |
| Publication Date | 2024/02 |
| Type | Research paper |
| Peer Review | Peer reviewed |
| Title | Increased contribution of small companies to late-entry drugs: a changing trend in FDA-approved drugs during the 2020s. |
| Contribution Type | Single Work |
| Journal | Drug Discovery Today |
| Journal Type | Another Country |
| Volume, Issue, Page | 29(2),pp.103866 |
| Authorship | Lead author,Corresponding author |
| Author and coauthor | Ryo Okuyama |
| Details | Small- and medium-sized enterprises (SMEs) have significantly boosted innovative drug discovery, whereas large pharmaceutical companies have focused on incremental drug innovation. I explored the evolving role of SMEs in late-entry drug discovery. A comparative analysis of new drugs approved by the US Food and Drug Administration (FDA) during the 2020s with those approved previously revealed that SMEs have expanded their role to late-entry drug discovery while maintaining their contribution to first-in-target drug discovery. I analyzed the characteristics of SMEs responsible for the discovery of late-entry drugs approved during the 2020s, and the modality, market entry timing, and differentiation points of the drugs. I also discuss encompassing opportunities for SMEs, pharmaceutical industry future alliance strategies, and the importance of startup promotion measures. |
| DOI | https://doi.org/10.1016/j.drudis.2023.103866 |